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Osteoradionecrosis of the jaws—a currentoverview—part 1: physiopathology and risk and predisposing factors. A reversal design is often used to study a dependent variable that may be tem-porarily affected by the experimental treatment. Prolongation of Na+ channel inactivationand suppression of high frequency firing has beendemonstrated. She also complains of weakness,loss of appetite, nausea and occasional vomiting. This is followed by hyperpigmen-tation and desquamation

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